study confirms that melatonin helps prevent the onset of Parkinson's.
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Thursday, March 24, 2011
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study confirms that melatonin helps prevent the onset of Parkinson's. Granada - Ideal
This work has also confirmed that substances similar to melatonin also have an important protective role against oxidative damage and inflammatory and recovery of complex I activity, the inhibition is a fundamental pathophysiological event in the development of Parkinson's disease, announced today the University of Granada.
The finding could have an important consequence for the design of new drugs to help prevent this disease, according to its authors, who point out that the cause is still unknown primary dopaminergic degeneration in Parkinson's disease, whose treatment is mainly symptomatic .
Research has tried to explain the role of nitric oxide (NO) in oxidative stress and mitochondrial dysfunction in the origin of this disease in the mouse model treated with MPTP (a toxin that mimics the biochemical and symptoms of the disease even in humans).
According to investigators, the development of new neuroprotective drugs "is hampered by our limited knowledge of the actual mechanisms by which dopaminergic neurons die."
Parkinson's disease is a 40% reduction in the activity of complex I of the electron transport chain in the substantia nigra of these patients, with a loss of between 70 and 80% of the neurons located in this tissue before symptoms appear.
In mice treated for this study complex I activity is reduced by 65% \u200b\u200bin the substantia nigra, and treatment with melatonin or its structural analogues counteract this reduction, normalizing mitochondrial function.
The work has been done by Ana López Ramírez, and some of their results have been published in scientific journals "Journal of Neuroscience Research" and "European Journal of Medicinal Chemistry."
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